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Loss of CYLD accelerates melanoma development and progression in the Tg(Grm1) melanoma mouse model

The deubiquitinase cylindromatosis (CYLD) is a well-known tumor suppressor, found to be down regulated in many cancer types including breast cancer, colon carcinoma and malignant melanoma. CYLD is suppressed in human melanoma cells by the transcriptional repressor SNAIL1 leading to an increase of th...

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Detalhes bibliográficos
Publicado no:Oncogenesis
Main Authors: de Jel, Miriam Martha, Schott, Mandy, Lamm, Susanne, Neuhuber, Winfried, Kuphal, Silke, Bosserhoff, Anja-Katrin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779913/
https://ncbi.nlm.nih.gov/pubmed/31591386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-019-0169-4
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