Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma

High malignancy and early metastasis are hallmarks of melanoma. Here, we report that the transcription factor Snail1 inhibits expression of the tumor suppressor CYLD in melanoma. As a direct consequence of CYLD repression, the protooncogene BCL-3 translocates into the nucleus and activates Cyclin D1...

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Detaylı Bibliyografya
Asıl Yazarlar: Massoumi, Ramin, Kuphal, Silke, Hellerbrand, Claus, Haas, Bodo, Wild, Peter, Spruss, Thilo, Pfeifer, Alexander, Fässler, Reinhard, Bosserhoff, Anja K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2009
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Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626666/
https://ncbi.nlm.nih.gov/pubmed/19124656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20082044
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