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Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma
High malignancy and early metastasis are hallmarks of melanoma. Here, we report that the transcription factor Snail1 inhibits expression of the tumor suppressor CYLD in melanoma. As a direct consequence of CYLD repression, the protooncogene BCL-3 translocates into the nucleus and activates Cyclin D1...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2626666/ https://ncbi.nlm.nih.gov/pubmed/19124656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20082044 |
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