CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways

The molecular mechanisms mediating CYLD tumor suppressor function appear to be manifold. Here, we demonstrated that, in contrast to the increased levels of pJNK, CYLD was decreased in a majority of melanoma cell lines and tissues examined. Exogenous expression of CYLD but not its catalytically defic...

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Hauptverfasser: Ke, Hengning, Augustine, Christina K, Gandham, Vineela D, Jin, Jane Y, Tyler, Douglas S, Akiyama, Steven K, Hall, Russell P, Zhang, Jennifer Y
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3485435/
https://ncbi.nlm.nih.gov/pubmed/22832488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2012.253
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