T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection

Innate and adaptive defense mechanisms protect the respiratory system from attack by microbes. Here, we present evidence that the bitter taste receptor T2R38 regulates the mucosal innate defense of the human upper airway. Utilizing immunofluorescent and live cell imaging techniques in polarized prim...

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Autori principali: Lee, Robert J., Xiong, Guoxiang, Kofonow, Jennifer M., Chen, Bei, Lysenko, Anna, Jiang, Peihua, Abraham, Valsamma, Doghramji, Laurel, Adappa, Nithin D., Palmer, James N., Kennedy, David W., Beauchamp, Gary K., Doulias, Paschalis-Thomas, Ischiropoulos, Harry, Kreindler, James L., Reed, Danielle R., Cohen, Noam A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3484455/
https://ncbi.nlm.nih.gov/pubmed/23041624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64240
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