Activation of airway epithelial bitter taste receptors by Pseudomonas aeruginosa quinolones modulates calcium, cyclic-AMP, and nitric oxide signaling

Bitter taste receptors (taste family 2 bitter receptor proteins; T2Rs), discovered in many tissues outside the tongue, have recently become potential therapeutic targets. We have shown previously that airway epithelial cells express several T2Rs that activate innate immune responses that may be impo...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Autores principales: Freund, Jenna R., Mansfield, Corrine J., Doghramji, Laurel J., Adappa, Nithin D., Palmer, James N., Kennedy, David W., Reed, Danielle R., Jiang, Peihua, Lee, Robert J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016477/
https://ncbi.nlm.nih.gov/pubmed/29748385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001005
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