Activation of airway epithelial bitter taste receptors by Pseudomonas aeruginosa quinolones modulates calcium, cyclic-AMP, and nitric oxide signaling

Bitter taste receptors (taste family 2 bitter receptor proteins; T2Rs), discovered in many tissues outside the tongue, have recently become potential therapeutic targets. We have shown previously that airway epithelial cells express several T2Rs that activate innate immune responses that may be impo...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Freund, Jenna R., Mansfield, Corrine J., Doghramji, Laurel J., Adappa, Nithin D., Palmer, James N., Kennedy, David W., Reed, Danielle R., Jiang, Peihua, Lee, Robert J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2018
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016477/
https://ncbi.nlm.nih.gov/pubmed/29748385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001005
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