T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection

Innate and adaptive defense mechanisms protect the respiratory system from attack by microbes. Here, we present evidence that the bitter taste receptor T2R38 regulates the mucosal innate defense of the human upper airway. Utilizing immunofluorescent and live cell imaging techniques in polarized prim...

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Détails bibliographiques
Auteurs principaux: Lee, Robert J., Xiong, Guoxiang, Kofonow, Jennifer M., Chen, Bei, Lysenko, Anna, Jiang, Peihua, Abraham, Valsamma, Doghramji, Laurel, Adappa, Nithin D., Palmer, James N., Kennedy, David W., Beauchamp, Gary K., Doulias, Paschalis-Thomas, Ischiropoulos, Harry, Kreindler, James L., Reed, Danielle R., Cohen, Noam A.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3484455/
https://ncbi.nlm.nih.gov/pubmed/23041624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64240
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