Bitter and sweet taste receptors regulate human upper respiratory innate immunity

Bitter taste receptors (T2Rs) in the human airway detect harmful compounds, including secreted bacterial products. Here, using human primary sinonasal air-liquid interface cultures and tissue explants, we determined that activation of a subset of airway T2Rs expressed in nasal solitary chemosensory...

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Bibliografiske detaljer
Main Authors: Lee, Robert J., Kofonow, Jennifer M., Rosen, Philip L., Siebert, Adam P., Chen, Bei, Doghramji, Laurel, Xiong, Guoxiang, Adappa, Nithin D., Palmer, James N., Kennedy, David W., Kreindler, James L., Margolskee, Robert F., Cohen, Noam A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934184/
https://ncbi.nlm.nih.gov/pubmed/24531552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72094
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