Bitter and sweet taste receptors regulate human upper respiratory innate immunity

Bitter taste receptors (T2Rs) in the human airway detect harmful compounds, including secreted bacterial products. Here, using human primary sinonasal air-liquid interface cultures and tissue explants, we determined that activation of a subset of airway T2Rs expressed in nasal solitary chemosensory...

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Detalhes bibliográficos
Main Authors: Lee, Robert J., Kofonow, Jennifer M., Rosen, Philip L., Siebert, Adam P., Chen, Bei, Doghramji, Laurel, Xiong, Guoxiang, Adappa, Nithin D., Palmer, James N., Kennedy, David W., Kreindler, James L., Margolskee, Robert F., Cohen, Noam A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934184/
https://ncbi.nlm.nih.gov/pubmed/24531552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72094
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