Bitter and sweet taste receptors regulate human upper respiratory innate immunity

Bitter taste receptors (T2Rs) in the human airway detect harmful compounds, including secreted bacterial products. Here, using human primary sinonasal air-liquid interface cultures and tissue explants, we determined that activation of a subset of airway T2Rs expressed in nasal solitary chemosensory...

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Main Authors: Lee, Robert J., Kofonow, Jennifer M., Rosen, Philip L., Siebert, Adam P., Chen, Bei, Doghramji, Laurel, Xiong, Guoxiang, Adappa, Nithin D., Palmer, James N., Kennedy, David W., Kreindler, James L., Margolskee, Robert F., Cohen, Noam A.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2014
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3934184/
https://ncbi.nlm.nih.gov/pubmed/24531552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72094
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