Mucosal Immunization with Live Attenuated Francisella novicida U112ΔiglB Protects against Pulmonary F. tularensis SCHU S4 in the Fischer 344 Rat Model

The need for an efficacious vaccine against Francisella tularensis is a consequence of its low infectious dose and high mortality rate if left untreated. This study sought to characterize a live attenuated subspecies novicida-based vaccine strain (U112ΔiglB) in an established second rodent model of...

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Hlavní autoři: Signarovitz, Aimee L., Ray, Heather J., Yu, Jieh-Juen, Guentzel, M. N., Chambers, James P., Klose, Karl E., Arulanandam, Bernard P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3484155/
https://ncbi.nlm.nih.gov/pubmed/23118885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047639
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