Enhancement of Vaccine Efficacy by Expression of a TLR5 Ligand in the Defined Live Attenuated Francisella tularensis subsp. novicida Strain U112▲iglB::fljB

Oral vaccination with the defined live attenuated Francisella novicida vaccine strain U112▲iglB has been demonstrated to induce protective immunity against pulmonary challenge with the highly human virulent F. tularensis strain SCHU S4. However, this vaccination regimen requires a booster dose in mi...

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Detalhes bibliográficos
Principais autores: Cunningham, Aimee L., Dang, Kim Minh, Yu, Jieh-Juen, Guentzel, M. Neal, Heidner, Hans, Klose, Karl E., Arulanandam, Bernard P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140432/
https://ncbi.nlm.nih.gov/pubmed/25050972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2014.07.038
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