Perforin- and Granzyme-Mediated Cytotoxic Effector Functions Are Essential for Protection against Francisella tularensis following Vaccination by the Defined F. tularensis subsp. novicida ΔfopC Vaccine Strain

A licensed vaccine against Francisella tularensis is currently not available. Two Francisella tularensis subsp. novicida (herein referred to by its earlier name, Francisella novicida) attenuated strains, the ΔiglB and ΔfopC strains, have previously been evaluated as potential vaccine candidates agai...

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Detalhes bibliográficos
Main Authors: Sanapala, Shilpa, Yu, Jieh-Juen, Murthy, Ashlesh K., Li, Weidang, Guentzel, M. Neal, Chambers, James P., Klose, Karl E., Arulanandam, Bernard P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370591/
https://ncbi.nlm.nih.gov/pubmed/22493083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00036-12
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