Perforin- and Granzyme-Mediated Cytotoxic Effector Functions Are Essential for Protection against Francisella tularensis following Vaccination by the Defined F. tularensis subsp. novicida ΔfopC Vaccine Strain

A licensed vaccine against Francisella tularensis is currently not available. Two Francisella tularensis subsp. novicida (herein referred to by its earlier name, Francisella novicida) attenuated strains, the ΔiglB and ΔfopC strains, have previously been evaluated as potential vaccine candidates agai...

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Bibliografiska uppgifter
Huvudupphovsmän: Sanapala, Shilpa, Yu, Jieh-Juen, Murthy, Ashlesh K., Li, Weidang, Guentzel, M. Neal, Chambers, James P., Klose, Karl E., Arulanandam, Bernard P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2012
Ämnen:
Microbial Immunity and Vaccines
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370591/
https://ncbi.nlm.nih.gov/pubmed/22493083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00036-12
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