2-Alkynoic fatty acids inhibit Topoisomerase IB from Leishmania donovani

2-Alkynoic fatty acids display antimycobacterial, antifungal, and pesticidal activities but their antiprotozoal activity has received little attention. In this work we synthesized the 2-octadecynoic acid (2-ODA), 2-hexadecynoic acid (2-HDA), and 2-tetradecynoic acid (2-TDA) and show that 2-ODA is th...

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Bibliographic Details
Main Authors: Carballeira, Néstor M., Cartagena, Michelle, Sanabria, David, Kaiser, Marcel, Tasdemir, Deniz, Prada, Christopher F., Reguera, Rosa M., Balaña-Fouce, Rafael
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483883/
https://ncbi.nlm.nih.gov/pubmed/22932312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.08.019
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