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Splenic Morphological Changes Are Accompanied by Altered Baseline Immunity in a Mouse Model of Sickle-Cell Disease

Although functional asplenia from infarctions may be a major contributor to increased infectious mortality in sickle-cell disease (SCD), this relationship has not been fully defined. We used the transgenic Berkeley SCD mouse to define blood and splenic immunophenotypic differences in this model comp...

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Bibliografiske detaljer
Main Authors: Szczepanek, Steven M., McNamara, Jeffrey T., Secor, Eric R., Natarajan, Prabitha, Guernsey, Linda A., Miller, Lauren A., Ballesteros, Enrique, Jellison, Evan, Thrall, Roger S., Andemariam, Biree
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2012
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483810/
https://ncbi.nlm.nih.gov/pubmed/23000264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.07.034
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