Transgenic sickle cell disease mice have high mortality and dysregulated immune responses after vaccination

BACKGROUND: Children with sickle cell disease (SCD) are susceptible to recurrent infections, which are often life threatening and necessitate frequent vaccinations. Given the altered baseline immunity and proinflammatory state associated with SCD, we sought to determine the relative safety and effic...

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Publicado en:Pediatr Res
Autores principales: Szczepanek, Steven M., Secor, Eric R., Bracken, Sonali J., Guernsey, Linda, Rafti, Ektor, Matson, Adam, Thrall, Roger S., Andemariam, Biree
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4487511/
https://ncbi.nlm.nih.gov/pubmed/23728384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2013.85
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