Transgenic sickle cell disease mice have high mortality and dysregulated immune responses after vaccination

BACKGROUND: Children with sickle cell disease (SCD) are susceptible to recurrent infections, which are often life threatening and necessitate frequent vaccinations. Given the altered baseline immunity and proinflammatory state associated with SCD, we sought to determine the relative safety and effic...

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Detalhes bibliográficos
Publicado no:Pediatr Res
Main Authors: Szczepanek, Steven M., Secor, Eric R., Bracken, Sonali J., Guernsey, Linda, Rafti, Ektor, Matson, Adam, Thrall, Roger S., Andemariam, Biree
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4487511/
https://ncbi.nlm.nih.gov/pubmed/23728384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2013.85
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