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A novel approach to the discovery of small molecule ligands of CDK2
In an attempt to identify novel small molecule ligands of CDK2 with potential as allosteric inhibitors, we devised a robust and cost-effective fluorescence-based high-throughput screening assay. The assay is based on the specific interaction of CDK2 with the extrinsic fluorophore 8-anilino-1-naphtha...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3483082/ https://ncbi.nlm.nih.gov/pubmed/22893598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201200316 |
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