Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide

We provide evidence that arsenic trioxide (As(2)O(3)) targets the BCR-ABL oncoprotein via a novel mechanism involving p62/SQSTM1-mediated localization of the oncoprotein to the autolysosomes and subsequent degradation mediated by the protease cathepsin B. Our studies demonstrate that inhibitors of a...

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Главные авторы: Goussetis, Dennis J., Gounaris, Elias, Wu, Edward J., Vakana, Eliza, Sharma, Bhumika, Bogyo, Matthew, Altman, Jessica K., Platanias, Leonidas C.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2012
Предметы:
Myeloid Neoplasia
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482863/
https://ncbi.nlm.nih.gov/pubmed/22898604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-402578
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