Targeting NAD(+) salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition

Malignant cells have a higher nicotinamide adenine dinucleotide (NAD(+)) turnover rate than normal cells, making this biosynthetic pathway an attractive target for cancer treatment. Here we investigated the biologic role of a rate-limiting enzyme involved in NAD(+) synthesis, Nampt, in multiple myel...

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Autors principals: Cea, Michele, Cagnetta, Antonia, Fulciniti, Mariateresa, Tai, Yu-Tzu, Hideshima, Teru, Chauhan, Dharminder, Roccaro, Aldo, Sacco, Antonio, Calimeri, Teresa, Cottini, Francesca, Jakubikova, Jana, Kong, Sun-Young, Patrone, Franco, Nencioni, Alessio, Gobbi, Marco, Richardson, Paul, Munshi, Nikhil, Anderson, Kenneth C.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
Matèries:
Lymphoid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3482862/
https://ncbi.nlm.nih.gov/pubmed/22955917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-416776
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