Activation of Nuclear Factor κB (NF-κB) in Prostate Cancer Is Mediated by Protein Kinase C ϵ (PKCϵ)

Protein kinase C ϵ (PKCϵ) has emerged as an oncogenic kinase and plays important roles in cell survival, mitogenesis and invasion. PKCϵ is up-regulated in most epithelial cancers, including prostate, breast, and lung cancer. Here we report that PKCϵ is an essential mediator of NF-κB activation in pr...

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Bibliographic Details
Main Authors: Garg, Rachana, Blando, Jorge, Perez, Carlos J., Wang, HongBin, Benavides, Fernando J., Kazanietz, Marcelo G.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481351/
https://ncbi.nlm.nih.gov/pubmed/22955280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.398925
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