Transcriptional Regulation of Oncogenic Protein Kinase Cϵ (PKCϵ) by STAT1 and Sp1 Proteins

Overexpression of PKCϵ, a kinase associated with tumor aggressiveness and widely implicated in malignant transformation and metastasis, is a hallmark of multiple cancers, including mammary, prostate, and lung cancer. To characterize the mechanisms that control PKCϵ expression and its up-regulation i...

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Autori principali: Wang, HongBin, Gutierrez-Uzquiza, Alvaro, Garg, Rachana, Barrio-Real, Laura, Abera, Mahlet B., Lopez-Haber, Cynthia, Rosemblit, Cinthia, Lu, Huaisheng, Abba, Martin, Kazanietz, Marcelo G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094091/
https://ncbi.nlm.nih.gov/pubmed/24825907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.548446
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