Function of carbonic anhydrase IX in glioblastoma multiforme

Carbonic anhydrase (CA) IX is over-expressed in glioblastoma; however, its functions in this context are unknown. Metabolically, glioblastomas are highly glycolytic, leading to a significant lactic acid load. Paradoxically, the intracellular pH is alkaline. We hypothesized that CAIX contributes to t...

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Autors principals: Proescholdt, Martin A., Merrill, Marsha J., Stoerr, Eva-Maria, Lohmeier, Annette, Pohl, Fabian, Brawanski, Alexander
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
Matèries:
Basic and Translational Investigations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480266/
https://ncbi.nlm.nih.gov/pubmed/23074198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos216
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