α-Synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2

Parkinson disease (PD) results from the slow, progressive loss of dopaminergic neurons in the substantia nigra. Alterations in α-synuclein (aSyn), such as mutations or multiplications of the gene, are thought to trigger this degeneration. Here, we show that aSyn disrupts mitogen-activated protein ki...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wang, Shaoxiao, Xu, Baoshan, Liou, Liang-Chun, Ren, Qun, Huang, Shile, Luo, Yan, Zhang, Zhaojie, Witt, Stephan N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2012
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479570/
https://ncbi.nlm.nih.gov/pubmed/22988096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206286109
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