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Targeting a pre-mRNA structure with bipartite antisense molecules modulates tau alternative splicing
Approximately 15% of human genetic diseases are estimated to involve dysregulation of alternative pre-mRNA splicing. Antisense molecules designed to alter these and other splicing events typically target continuous linear sequences of the message. Here, we show that a structural feature in a pre-mRN...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3479178/ https://ncbi.nlm.nih.gov/pubmed/22844088 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks710 |
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