RNA Secondary Structure-Based Design of Antisense Peptide Nucleic Acids for Modulating Disease-Associated Aberrant Tau Pre-mRNA Alternative Splicing

Alternative splicing of tau pre-mRNA is regulated by a 5′ splice site (5′ss) hairpin present at the exon 10–intron 10 junction. Single mutations within the hairpin sequence alter hairpin structural stability and/or the binding of splicing factors, resulting in disease-causing aberrant splicing of ex...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Molecules
Hlavní autoři: Ong, Alan Ann Lerk, Tan, Jiazi, Bhadra, Malini, Dezanet, Clément, Patil, Kiran M., Chong, Mei Sian, Kierzek, Ryszard, Decout, Jean-Luc, Roca, Xavier, Chen, Gang
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6720520/
https://ncbi.nlm.nih.gov/pubmed/31434312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24163020
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky