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Mechanism of Transcription Initiation at an Activator-Dependent Promoter Defined by Single-Molecule Observation

Understanding the pathway and kinetic mechanisms of transcription initiation is essential for quantitative understanding of gene regulation, but initiation is a multistep process, the features of which can be obscured in bulk analysis. We used a multiwavelength single-molecule fluorescence colocaliz...

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Autors principals: Friedman, Larry J., Gelles, Jeff
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3479156/
https://ncbi.nlm.nih.gov/pubmed/22341441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.01.018
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