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Single-molecule Studies of Origin Licensing Reveal Mechanisms Ensuring Bidirectional Helicase Loading

Loading of the ring-shaped Mcm2-7 replicative helicase around DNA licenses eukaryotic origins of replication. During loading, Cdc6, Cdt1 and the origin-recognition complex (ORC) assemble two heterohexameric Mcm2-7 complexes into a head-to-head double hexamer that facilitates bidirectional replicatio...

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Publicat a:Cell
Autors principals: Ticau, Simina, Friedman, Larry J., Ivica, Nikola A., Gelles, Jeff, Bell, Stephen P.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4445235/
https://ncbi.nlm.nih.gov/pubmed/25892223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.03.012
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