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The Dynamics of Eukaryotic Replication Initiation: Origin Specificity, Licensing, and Firing at the Single-molecule Level
Eukaryotic replication initiation is highly regulated and dynamic. It begins with the Origin Recognition Complex (ORC) binding DNA sites called origins of replication. ORC, together with Cdc6 and Cdt1, mediate pre-Replicative Complex (pre-RC) assembly by loading a double hexamer of Mcm2-7: the core...
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| Udgivet i: | Mol Cell |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4427541/ https://ncbi.nlm.nih.gov/pubmed/25921072 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.03.017 |
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