The Dynamics of Eukaryotic Replication Initiation: Origin Specificity, Licensing, and Firing at the Single-molecule Level

Eukaryotic replication initiation is highly regulated and dynamic. It begins with the Origin Recognition Complex (ORC) binding DNA sites called origins of replication. ORC, together with Cdc6 and Cdt1, mediate pre-Replicative Complex (pre-RC) assembly by loading a double hexamer of Mcm2-7: the core...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Duzdevich, Daniel, Warner, Megan D., Ticau, Simina, Ivica, Nikola A., Bell, Stephen P., Greene, Eric C.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4427541/
https://ncbi.nlm.nih.gov/pubmed/25921072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.03.017
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