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Replication origin–flanking roadblocks reveal origin-licensing dynamics and altered sequence dependence

In eukaryotes, DNA replication initiates from multiple origins of replication for timely genome duplication. These sites are selected by origin licensing, during which the core enzyme of the eukaryotic DNA replicative helicase, the Mcm2-7 (minichromosome maintenance) complex, is loaded at each origi...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Warner, Megan D., Azmi, Ishara F., Kang, Sukhyun, Zhao, Yanding, Bell, Stephen P.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766963/
https://ncbi.nlm.nih.gov/pubmed/29074622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.815639
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