Rapid DNA replication origin licensing protects stem cell pluripotency

Complete and robust human genome duplication requires loading minichromosome maintenance (MCM) helicase complexes at many DNA replication origins, an essential process termed origin licensing. Licensing is restricted to G1 phase of the cell cycle, but G1 length varies widely among cell types. Using...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Matson, Jacob Peter, Dumitru, Raluca, Coryell, Philip, Baxley, Ryan M, Chen, Weili, Twaroski, Kirk, Webber, Beau R, Tolar, Jakub, Bielinsky, Anja-Katrin, Purvis, Jeremy E, Cook, Jeanette Gowen
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Chromosomes and Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720591/
https://ncbi.nlm.nih.gov/pubmed/29148972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.30473
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