Analysis of the Tau-Associated Proteome Reveals that Exchange of Hsp70 for Hsp90 Is Involved in Tau Degradation

The microtubule associated protein tau (MAPT/tau) aberrantly accumulates in fifteen neurodegenerative diseases, termed tauopathies. One way to treat tauopathies may be to accelerate tau clearance, but the molecular mechanisms governing tau stability are not yet clear. We recently identified chemical...

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Bibliografiske detaljer
Main Authors: Thompson, Andrea D., Scaglione, K. Matthew, Prensner, John, Gillies, Anne T., Chinnaiyan, Arul, Paulson, Henry L., Jinwal, Umesh K., Dickey, Chad A., Gestwicki, Jason E.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3477299/
https://ncbi.nlm.nih.gov/pubmed/22769591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb3002599
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