Discovery of Novel Inhibitors of a Disintegrin and Metalloprotease 17 (ADAM17) Using Glycosylated and Non-glycosylated Substrates

A disintegrin and metalloprotease (ADAM) proteases are implicated in multiple diseases, but no drugs based on ADAM inhibition exist. Most of the ADAM inhibitors developed to date feature zinc-binding moieties that target the active site zinc, which leads to a lack of selectivity and off-target toxic...

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Hlavní autoři: Minond, Dmitriy, Cudic, Mare, Bionda, Nina, Giulianotti, Marc, Maida, Laura, Houghten, Richard A., Fields, Gregg B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476313/
https://ncbi.nlm.nih.gov/pubmed/22927435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.389114
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