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Shrinkage in Nonlinear Mixed-Effects Population Models: Quantification, Influencing Factors, and Impact

Shrinkage of empirical Bayes estimates (EBEs) of posterior individual parameters in mixed-effects models has been shown to obscure the apparent correlations among random effects and relationships between random effects and covariates. Empirical quantification equations have been widely used for popu...

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Detalhes bibliográficos
Main Authors: Xu, Xu Steven, Yuan, Min, Karlsson, Mats O., Dunne, Adrian, Nandy, Partha, Vermeulen, An
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475840/
https://ncbi.nlm.nih.gov/pubmed/22993107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-012-9407-9
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