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Shrinkage in Nonlinear Mixed-Effects Population Models: Quantification, Influencing Factors, and Impact
Shrinkage of empirical Bayes estimates (EBEs) of posterior individual parameters in mixed-effects models has been shown to obscure the apparent correlations among random effects and relationships between random effects and covariates. Empirical quantification equations have been widely used for popu...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Springer US
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3475840/ https://ncbi.nlm.nih.gov/pubmed/22993107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-012-9407-9 |
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