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Nonlinearity detection: Advantages of nonlinear mixed-effects modeling

The purpose of this study was to address the question of whether the use of nonlinear mixed-effect models has an impact on the detection and characterization of nonlinear processes (pharmacokinetic and pharmacodynamic) in rich data obtained from a few subjects. Simulations were used to assess the di...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Jonsson, E. Niclas, Karlsson, Mats O., Wade, Janet R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer-Verlag 2000
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761142/
https://ncbi.nlm.nih.gov/pubmed/11741248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/ps020332
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