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Nonlinearity detection: Advantages of nonlinear mixed-effects modeling
The purpose of this study was to address the question of whether the use of nonlinear mixed-effect models has an impact on the detection and characterization of nonlinear processes (pharmacokinetic and pharmacodynamic) in rich data obtained from a few subjects. Simulations were used to assess the di...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer-Verlag
2000
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2761142/ https://ncbi.nlm.nih.gov/pubmed/11741248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/ps020332 |
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