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Prediction-Corrected Visual Predictive Checks for Diagnosing Nonlinear Mixed-Effects Models

Informative diagnostic tools are vital to the development of useful mixed-effects models. The Visual Predictive Check (VPC) is a popular tool for evaluating the performance of population PK and PKPD models. Ideally, a VPC will diagnose both the fixed and random effects in a mixed-effects model. In m...

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Detalhes bibliográficos
Main Authors: Bergstrand, Martin, Hooker, Andrew C., Wallin, Johan E., Karlsson, Mats O.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085712/
https://ncbi.nlm.nih.gov/pubmed/21302010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-011-9255-z
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