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Development of visual predictive checks accounting for multimodal parameter distributions in mixture models
The assumption of interindividual variability being unimodally distributed in nonlinear mixed effects models does not hold when the population under study displays multimodal parameter distributions. Mixture models allow the identification of parameters characteristic to a subpopulation by describin...
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| Publicado no: | J Pharmacokinet Pharmacodyn |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6560505/ https://ncbi.nlm.nih.gov/pubmed/30968312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-019-09632-9 |
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