Biosynthesis of 3-Iodothyronamine (T(1)AM) Is Dependent on the Sodium-Iodide Symporter and Thyroperoxidase but Does Not Involve Extrathyroidal Metabolism of T(4)

3-Iodothyronamine (T(1)AM) is an endogenous thyroid hormone derivative with unknown biosynthetic origins. Structural similarities have led to the hypothesis that T(1)AM is an extrathyroidal metabolite of T(4). This study uses an isotope-labeled T(4) [heavy-T(4) (H-T(4))] that can be distinguished fr...

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Autori principali: Hackenmueller, Sarah A., Marchini, Maja, Saba, Alessandro, Zucchi, Riccardo, Scanlan, Thomas S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2012
Soggetti:
Thyroid-TRH-TSH
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3473208/
https://ncbi.nlm.nih.gov/pubmed/22948220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1254
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