Biosynthesis of 3-Iodothyronamine (T(1)AM) Is Dependent on the Sodium-Iodide Symporter and Thyroperoxidase but Does Not Involve Extrathyroidal Metabolism of T(4)

3-Iodothyronamine (T(1)AM) is an endogenous thyroid hormone derivative with unknown biosynthetic origins. Structural similarities have led to the hypothesis that T(1)AM is an extrathyroidal metabolite of T(4). This study uses an isotope-labeled T(4) [heavy-T(4) (H-T(4))] that can be distinguished fr...

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Detalhes bibliográficos
Main Authors: Hackenmueller, Sarah A., Marchini, Maja, Saba, Alessandro, Zucchi, Riccardo, Scanlan, Thomas S.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2012
Assuntos:
Thyroid-TRH-TSH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3473208/
https://ncbi.nlm.nih.gov/pubmed/22948220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1254
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