Biosynthesis of 3-Iodothyronamine (T(1)AM) Is Dependent on the Sodium-Iodide Symporter and Thyroperoxidase but Does Not Involve Extrathyroidal Metabolism of T(4)

3-Iodothyronamine (T(1)AM) is an endogenous thyroid hormone derivative with unknown biosynthetic origins. Structural similarities have led to the hypothesis that T(1)AM is an extrathyroidal metabolite of T(4). This study uses an isotope-labeled T(4) [heavy-T(4) (H-T(4))] that can be distinguished fr...

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Bibliographic Details
Main Authors: Hackenmueller, Sarah A., Marchini, Maja, Saba, Alessandro, Zucchi, Riccardo, Scanlan, Thomas S.
Format: Artigo
Language:Inglês
Published: Endocrine Society 2012
Subjects:
Thyroid-TRH-TSH
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3473208/
https://ncbi.nlm.nih.gov/pubmed/22948220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1254
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