Excess Iodide Induces an Acute Inhibition of the Sodium/Iodide Symporter in Thyroid Male Rat Cells by Increasing Reactive Oxygen Species

Na(+)/I(−) symporter (NIS) mediates iodide (I(−)) uptake in the thyroid gland, the first and rate-limiting step in the biosynthesis of the thyroid hormones. The expression and function of NIS in thyroid cells is mainly regulated by TSH and by the intracellular concentration of I(−). High doses of I(...

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Bibliografske podrobnosti
izdano v:Endocrinology
Main Authors: Arriagada, Alejandro A., Albornoz, Eduardo, Opazo, Ma. Cecilia, Becerra, Alvaro, Vidal, Gonzalo, Fardella, Carlos, Michea, Luis, Carrasco, Nancy, Simon, Felipe, Elorza, Alvaro A., Bueno, Susan M., Kalergis, Alexis M., Riedel, Claudia A.
Format: Artigo
Jezik:Inglês
Izdano: Endocrine Society 2015
Teme:
Thyroid-TRH-TSH
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393323/
https://ncbi.nlm.nih.gov/pubmed/25594695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1371
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