Excess Iodide Induces an Acute Inhibition of the Sodium/Iodide Symporter in Thyroid Male Rat Cells by Increasing Reactive Oxygen Species

Na(+)/I(−) symporter (NIS) mediates iodide (I(−)) uptake in the thyroid gland, the first and rate-limiting step in the biosynthesis of the thyroid hormones. The expression and function of NIS in thyroid cells is mainly regulated by TSH and by the intracellular concentration of I(−). High doses of I(...

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Publicado no:Endocrinology
Main Authors: Arriagada, Alejandro A., Albornoz, Eduardo, Opazo, Ma. Cecilia, Becerra, Alvaro, Vidal, Gonzalo, Fardella, Carlos, Michea, Luis, Carrasco, Nancy, Simon, Felipe, Elorza, Alvaro A., Bueno, Susan M., Kalergis, Alexis M., Riedel, Claudia A.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2015
Assuntos:
Thyroid-TRH-TSH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393323/
https://ncbi.nlm.nih.gov/pubmed/25594695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1371
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