Excess Iodide Induces an Acute Inhibition of the Sodium/Iodide Symporter in Thyroid Male Rat Cells by Increasing Reactive Oxygen Species

Na(+)/I(−) symporter (NIS) mediates iodide (I(−)) uptake in the thyroid gland, the first and rate-limiting step in the biosynthesis of the thyroid hormones. The expression and function of NIS in thyroid cells is mainly regulated by TSH and by the intracellular concentration of I(−). High doses of I(...

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Publicado en:Endocrinology
Autores principales: Arriagada, Alejandro A., Albornoz, Eduardo, Opazo, Ma. Cecilia, Becerra, Alvaro, Vidal, Gonzalo, Fardella, Carlos, Michea, Luis, Carrasco, Nancy, Simon, Felipe, Elorza, Alvaro A., Bueno, Susan M., Kalergis, Alexis M., Riedel, Claudia A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Endocrine Society 2015
Materias:
Thyroid-TRH-TSH
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393323/
https://ncbi.nlm.nih.gov/pubmed/25594695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1371
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