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The submitochondrial distribution of ubiquinone affects respiration in long-lived Mclk1(+/−) mice

Mclk1 (also known as Coq7) and Coq3 code for mitochondrial enzymes implicated in the biosynthetic pathway of ubiquinone (coenzyme Q or UQ). Mclk1(+/−) mice are long-lived but have dysfunctional mitochondria. This phenotype remains unexplained, as no changes in UQ content were observed in these mutan...

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Detalhes bibliográficos
Main Authors: Lapointe, Jérôme, Wang, Ying, Bigras, Eve, Hekimi, Siegfried
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471228/
https://ncbi.nlm.nih.gov/pubmed/23045551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201203090
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