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Reversal of the Mitochondrial Phenotype and Slow Development of Oxidative Biomarkers of Aging in Long-lived Mclk1(+/−) Mice

Although there is a consensus that mitochondrial function is somehow linked to the aging process, the exact role played by mitochondria in this process remains unresolved. The discovery that reduced activity of the mitochondrial enzyme CLK-1/MCLK1 (also known as COQ7) extends lifespan in both Caenor...

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Detalhes bibliográficos
Main Authors: Lapointe, Jérôme, Stepanyan, Zaruhi, Bigras, Eve, Hekimi, Siegfried
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740461/
https://ncbi.nlm.nih.gov/pubmed/19478076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.006569
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