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Early Mitochondrial Dysfunction in Long-lived Mclk1(+/-) Mice
Reduced activity of CLK-1/MCLK1 (also known as COQ7), a mitochondrial enzyme that is necessary for ubiquinone biosynthesis, prolongs the lifespan of nematodes and mice by a mechanism that is distinct from that of the insulin signaling pathway. Here we show that 2-fold reduction of MCLK1 expression i...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3258865/ https://ncbi.nlm.nih.gov/pubmed/18635541 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803287200 |
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