Positive feedback between p53 and TRF2 in telomere damage signaling and cellular senescence

The telomere-capping complex (shelterin) protects functional telomeres from initiating unwanted DNA damage response. Uncapped telomeres at the end of cellular replicative lifespan lose this protective mechanism and trigger DNA damage signaling to activate p53 and thereby induce replicative senescenc...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Fujita, Kaori, Horikawa, Izumi, Mondal, Abdul M., Miller Jenkins, Lisa M., Appella, Ettore, Vojtesek, Borivoj, Bourdon, Jean-Christophe, Lane, David P., Harris, Curtis C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3470109/
https://ncbi.nlm.nih.gov/pubmed/21057505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2123
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk