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Positive feedback between p53 and TRF2 in telomere damage signaling and cellular senescence
The telomere-capping complex (shelterin) protects functional telomeres from initiating unwanted DNA damage response. Uncapped telomeres at the end of cellular replicative lifespan lose this protective mechanism and trigger DNA damage signaling to activate p53 and thereby induce replicative senescenc...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3470109/ https://ncbi.nlm.nih.gov/pubmed/21057505 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2123 |
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