Δ133p53 represses p53-inducible senescence genes and enhances the generation of human induced pluripotent stem cells

p53 functions to induce cellular senescence, which is incompatible with self-renewal of pluripotent stem cells such as induced pluripotent stem cells (iPSC) and embryonic stem cells (ESC). However, p53 also has essential roles in these cells through DNA damage repair for maintaining genomic integrit...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Death Differ
Hauptverfasser: Horikawa, Izumi, Park, Kye-yoon, Isogaya, Kazunobu, Hiyoshi, Yukiharu, Li, Han, Anami, Katsuhiro, Robles, Ana I, Mondal, Abdul M, Fujita, Kaori, Serrano, Manuel, Harris, Curtis C
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5442472/
https://ncbi.nlm.nih.gov/pubmed/28362428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.48
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