Positive feedback between p53 and TRF2 in telomere damage signaling and cellular senescence

The telomere-capping complex (shelterin) protects functional telomeres from initiating unwanted DNA damage response. Uncapped telomeres at the end of cellular replicative lifespan lose this protective mechanism and trigger DNA damage signaling to activate p53 and thereby induce replicative senescenc...

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Autores principales: Fujita, Kaori, Horikawa, Izumi, Mondal, Abdul M., Miller Jenkins, Lisa M., Appella, Ettore, Vojtesek, Borivoj, Bourdon, Jean-Christophe, Lane, David P., Harris, Curtis C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3470109/
https://ncbi.nlm.nih.gov/pubmed/21057505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2123
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