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Protein Folding: Adding a Nucleus to Guide Helix Docking Reduces Landscape Roughness
The elongated three-helix‐bundle spectrin domains R16 and R17 fold and unfold unusually slowly over a rough energy landscape, in contrast to the homologue R15, which folds fast over a much smoother, more typical landscape. R15 folds via a nucleation–condensation mechanism that guides the docking of...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Elsevier
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3469821/ https://ncbi.nlm.nih.gov/pubmed/22917971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.08.003 |
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