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Experimental evidence for a frustrated energy landscape in a 3-helix bundle protein family

Energy landscape theory is a powerful tool for understanding the structure and dynamics of complex molecular systems, in particular biological macromolecules1. The primary sequence of a protein defines its free energy landscape, and thus determines the folding pathway and the rate constants of foldi...

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Autors principals: Wensley, Beth G., Batey, Sarah, Bone, Fleur A. C., Chan, Zheng Ming, Tumelty, Nuala R., Steward, Annette, Kwa, Lee Gyan, Borgia, Alessandro, Clarke, Jane
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2851140/
https://ncbi.nlm.nih.gov/pubmed/20130652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08743
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